CCR 6 IL - 17 Express the Chemokine Receptor Human T Cells That Are Able to Produce
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Human memory CCR 4 1 CD 8 1 T cell subset has the ability to produce multiple cytokines
The CC chemokine receptor (CCR)4 is associated with trafficking of specialized cutaneous memory type 2 Th cells in the skin. However, a CD8 1 T cell population expressing CCR4 still remains uncharacterized. In the present study, we investigated the expression and function of CCR4 on human CD8 T cells and characterized CCR4CD8 human T cells. Multi-color flow cytometric analysis revealed that CCR...
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This report shows that interleukin (IL) 17-producing T helper type 17 (Th17) cells predominantly express CC chemokine receptor (CCR) 6 in an animal model of rheumatoid arthritis (RA). Th17 cells induced in vivo in normal mice via homeostatic proliferation similarly express CCR6, whereas those inducible in vitro by transforming growth factor beta and IL-6 additionally need IL-1 and neutralizatio...
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BACKGROUND Natural killer (NK) cells have both cytolytic and immunoregulatory functions. We recently described that these cells release the inflammatory cytokines IL-17 and IFN-γ. However, the precise identity of the NK cell subset(s) that secrete these cytokines is not known. METHODOLOGY/PRINCIPAL FINDINGS To isolate the cells secreting IL-17 and IFN-γ, we took advantage of the findings that...
متن کاملCirculating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
The C-type lectin-like receptor CD161, which has recently been described to promote T cell expansion, is expressed on a discrete subset of human CD4 T cells. The function of such cells, however, has remained elusive. We now demonstrate that CD161(+) CD4 T cells comprise a circulating and gut-resident T helper 17 (Th17) cell population. During Crohn's disease (CD), these CD161(+) cells display a...
متن کاملThe phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation.
T helper 17 (T(h)17) cells represent a new subset of CD4+ effector T cells which have been described in both mice and humans. However, some differences seem to exist between murine and human T(h)17 cells with regard to their features, origin and role in immunopathology. Murine T(h)17 cells share their developmental origin with Foxp3+ Treg cells, indeed naive T-cell precursors can be differentia...
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